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It was observed that the overexpression of PINK1 in a Drosophila model of HD resulted in the amelioration of Parkin-mediated mitophagy defects and the attenuation of mHtt-induced neurotoxicity

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Its role is complementary and can vary depending on whether a direct or precursor-based approach is preferred

Side Effects and Safety L-arginine side effects primarily involve gastrointestinal symptoms including nausea, diarrhea, and abdominal discomfort, particularly at higher intake levels

Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial